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Each operates differently, each is contested by different stakeholders, and each is the subject of separate legislative reform proposals
Marita says, Having a strong development program in place is crucial
In addition, in the cases of methylmalonic acidemia with homocystinuria due to pathogenic variants in the methionine synthase (MTR) gene the consequent reductions in S-adenosylmethionine (SAM or AdoMet) synthesis results in loss of efficient phospholipid methylation leading to defects in myelin sheath membrane lipid homeostasis which contributes to the neural pathology of these disorders
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