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References to food supplements have not been evaluated by the EFSA (European Food Safety Authority) and are not intended to diagnose, treat, cure, or prevent any disease
So, peripherally dosed long-acting GLP-1RAs have the ability to access neurons in both the CVOs and in a few select sites in the hypothalamus, but do not broadly cross the blood brainbarrier
On the other hand, Semaglutide mimics the activity of GLP-1, a hormone naturally released by the intestines in response to intake of food
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