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In the cryo-EM structure, the indole side chain of Trp33 folds down like a lid over one branch of the orforglipron molecule (an indoletetrahydropyran moiety), forming aromatic and hydrophobic interactions that are essential for high-affinity binding
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Coenzyme Q10 (CoQ10) is essential to mitochondrial energy metabolism, and a powerful inhibitor of oxidative stress (Littarru 2007)
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