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Interestingly, the combination of semaglutide and trevogrumab alone (without garetosmab) was better tolerated, with discontinuation rates similar to semaglutide monotherapy, suggesting that garetosmab may contribute to the increased side effects in the triplet regimen

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Measures to support patient adherence are discussed in a later section

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Pramila Gupta adds, For patients with melasma, consistency is more important than speed

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