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One meta-analysis compared the highest dose of tirzepatide (15 mg) to the highest dose of semaglutide (2 mg) and found that tirzepatide resulted in a greater weight loss at a 17.8% reduction in body weight versus 12.4% for semaglutide

Food and Drug Administration (FDA) conducted an internal review on the safety of GLP-1s that analyzed clinical reports of suicidal thoughts associated with using those medications

Understanding the dos and donts when combining semaglutide with other prescriptions is key to safeguarding your health

Note, the recent ESC guidelines recommending SGLT2i and GLP-1RA therapy do so irrespective of background metformin therapy