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IGF-1 LR3, by contrast, works through the classic IGF-1 receptor signaling cascade, activating the PI3K/Akt/mTOR pathway and supporting satellite cells once they have already entered the proliferative and differentiation phase

This pharmacokinetic profile provides a natural taper period, though patients should understand that appetite suppression and glycemic benefits will progressively decline during this window

The 2025 review also reported that in a large retrospective study of 461,328 adults initiating GLP-1 therapy, over 22% developed at least one nutritional deficiency within 12 months, with vitamin D the most common deficiency identified

Ultimately, this results in the modulation of the sleeps architecture and optimization of the various stages of sleep, especially the highly restorative slow-wave sleep (SWS), often referred to as deep sleep or stage 3 sleep [1, 2]