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From a drug interaction perspective, the most clinically significant effect of Wegovy is its impact on gastric emptying

The dose-response question is unanswered While the meta-analysis showed that 5 mg produced significant CRP reduction, we do not know where the minimum effective anti-inflammatory dose falls

Some patients benefit from a lower maintenance dose of semaglutide rather than complete discontinuation, which allows ongoing appetite management at lower cost while preventing the weight-loss plateau effect that can occur with continuous high-dose therapy

But slowed digestion also changes how nutrients and food byproducts break down