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Results from two consecutive trials are presented demonstrating how the pharmacokinetics of oral semaglutide are affected (1) by different combinations of water volume with dosing and duration of post-dose fasting (the dosing conditions trial) and (2) by dosing in the fed state (the food-effect trial)
Other evidence suggests the L-cells located in the proximal jejunum are sufficient to account for the early-phase secretion through direct contact with luminal nutrients
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