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Furthermore, it could be shown that DPP4 inhibition is clearly associated with significantly increased -cell mass and function in several models of T2DM (134136)
We also tested a non-CRC model, the osteosarcoma U2OS cell line, which is wild-type for APC, KRAS and p53, and confirmed a similar 5FU-driven change in mitochondrial mass and morphology (Extended Data Fig
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