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While they found better skin outcomes in participants who used hydroquinone cream (a common melasma intervention), they also concluded that topical silymarin was also effective and produced fewer side effects.28 Wrinkles A lack of skin moisture is one of the factors behind fine lines and wrinkles.29 According to a 2012 study published in the African Journal of Biotechnology , milk thistle extract, emulsified into a topical cream, may help combat wrinkle formation by boosting moisture retention and preventing transepidermal water loss.30 An important caveat to consider is that all of our top recommended milk thistles are oral supplements, and research on oral milk thistle for the above purposes is somewhat lacking

The dosing here is drawn from reference protocols for research and educational purposes only and is not medical advice

We incorporate Phovia as part of a comprehensive rehabilitation plan for horses with: Wounds and abrasions Surgical incisions Skin infections and dermatitis Burns and compromised or poorly vascularized tissues Phovia works by accelerating cellular tissue repair and regeneration on a cellular level, reducing healing time and supporting stronger tissue recovery

16 One study compared GHK-Cu dosed at 15mg/kg nasally daily for 8 weeks in mice to placebo (saline)