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In contrast to chronic treatment with intact hGH, chronic treatment with AOD9604 showed no adverse effect on insulin sensitivity of the animals, as demonstrated with euglycemic clamp techniques Another study published in 2001 found the same thing, yet the results were very different for lean rats versus obese rats: Both hGH and AOD significantly reduced body weight gain in obese mice
Gray WM, Kepinski S, Rouse D, Leyser O, Estelle M
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These SC-islets are often more than 80% endocrine, capable of secreting insulin following glucose stimulation, and capable of restoring normoglycemia after transplantation into diabetic mice (203, 204, 207)
