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ATGL (designated PNPLA2 in the patatin domain nomenclature) preferentially hydrolyzes long-chain fatty acids esterified to the sn -1 and sn -2 position of triglycerides, but does not hydrolyze fatty acids from the sn -3 position
However, its remarkable ability to promote weight loss has made it a game-changer in the field of medical weight management
Similar to ACP, FDH requires a 4-phosphopantetheine prosthetic group for its biological activity
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