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Cell Prolif 2020;53:e12909

It is reported that intratumoral cDCs are responsible for intratumoral CTL proliferation both in vivo and in vitro (Diao et al., 2011), and they are the only group of phagocytosing tumor myeloid cells that can stimulate CD8+ T cell proliferation ( Effective T cell activation by DCs require DC maturation, a process happens after DC exposing to antigen, characterized by increased membrane expression of MHC and co-stimulatory molecules (CD80, CD86, CD40) (Drakes and Stiff, 2018)