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Read clinical review Clinical Reviews GIP/GLP-1 Dual Agonists: Special-Populations Prescribing Summary Evidence-based prescribing guide for tirzepatide and other GIP/GLP-1 dual agonists in renal impairment, hepatic disease, older adults, adolescents, pregnancy, and heart failure with preserved ejection fraction
As an amino acid derivative it carries a carboxylate and a hydroxyl group on a trimethylammonium backbone, and it exists as a zwitterion (inner salt) at physiological pH
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Specifically, macrophages activate TNF-like weak inducer of apoptosis (TWEAK) through the CCL5/TRAF6/NF-B pathway, leading to muscle atrophy
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