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The recommended washout period differs by product: the UK Summary of Product Characteristics (SmPC) for semaglutide (Wegovy) advises stopping treatment at least two months before a planned pregnancy, whilst the SmPC for tirzepatide (Mounjaro) advises stopping at least one month before
Veldhuis, W
However, because it remains unlicensed, any supply or use outside of an approved clinical trial setting is not sanctioned by UK regulatory authorities and may be unlawful
Lastly, the systemic effects of GLP-1RAs, such as body weight loss [103] and potential reduction in muscle mass [104], pose significant challenges for elderly individuals with neurodegenerative diseases
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