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Subsequently, the D m values of the four drugs were evaluated according to the Chou-Talalay median-effect principle as follows: Where D represents the treated dose and D m denotes the dose required to produce the median-effect (e.g., 50% inhibition of ROS generation, corresponding to IC50), and m is the Hill-type coefficient, which signifies the shape of the dose-effect curve

FDA compounding review On December 4, 2024, the FDA Pharmacy Compounding Advisory Committee (PCAC) reviewed AOD-9604 (free base) and AOD-9604 acetate against the 503A Bulks List

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