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The novel antidiabetic drugs, such as sodium glucose cotransporter 2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase 4 inhibitors (DPP4i), have demonstrated beneficial effects on cardiovascular outcomes in patients with DM [11]

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In particular the Asp 73 -Lys 76 loop of Fab 3F52 overlaps with Thr 13 only 6 residues away from the N-terminal histidine (His 7 ) of GLP-1 which is critical for receptor activation

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