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These medications slow the emptying of the stomach, reduce hunger signals, and enhance insulin sensitivity, which can support weight loss and help manage conditions like type 2 diabetes

Once secreted, GLP-1 has a very short half-life of approximately 1-2 minutes in the circulation, as it is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)

Acute Critical Illness Increased mortality in patients with acute critical illness due to complications following open heart surgery, abdominal surgery or multiple accidental trauma, or those with acute respiratory failure has been reported after treatment with pharmacologic amounts of growth hormone