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According to the article Key Substance Use and Mental Health Indicators in the United States: Results from the 2020 National Survey on Drug Use and Health published by the Substance Abuse and Mental Health Services Administration (SAMHSA), approximately 9.5 million people in the U.S

Wegovy (for weight management) uses a higher maintenance dose

In particular, Ex4 reduces the intake of natural and artificial rewards, effects that to some extent involve activation of GLP-1 receptors in the nucleus tractus solitarius (NTS)

Common side effects include nausea, vomiting, and constipation, typically diminishing over weeks