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found that GLP-1 RAs are associated with an increased risk of gallbladder and biliary diseases (including cholelithiasis and cholecystitis), particularly at higher doses, longer treatment durations, and when used for weight loss [129]

Sticking to the recommended schedule makes the drug work better

However, there are a few guidelines: You have obesity a body mass index (BMI) of 30 or higher You have prediabetes or diabetes You have weight-related cardiovascular issues You have a history of cardiovascular disease Your weight is causing you discomfort, such as joint pain Please note that BMI numbers are guidelines

Side effects primarily gastrointestinal can be significant and require monitoring