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Apply numbing cream (lidocaine 5%) to the scalp

This can be for several reasons, including how the patient tolerates the medications side effects and their clinical responses to the treatment. A typical dosage chart increases until the goal dose is met Dosage charts show patients the trajectory of their progress

The combination treatment enhanced mitochondrial oxidative phosphorylation, reduced glycolysis, and increased reactive oxygen species production, leading to mitochondrial membrane depolarization, activation of apoptosis, and suppression of cell proliferation