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For inhibition of thioredoxin reductase or glutathione reductase activity, cells were subsequently treated with 1 M auranofin (Sigma Aldrich, Darmstadt, Germany) or 50 M 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) (Sigma Aldrich, Darmstadt, Germany) respectively for 1 h

Methods: HAE-C1-INH was diagnosed based on complement measurements, while SERPING1 was screened using bidirectional sequencing following PCR amplification and multiplex ligation-dependent probe amplification

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Individuals who are pregnant, nursing, or managing certain thyroid conditions should consult a physician before pursuing GLP-1 therapy of any kind