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Patients who have a history of stimulant use but are no longer on ADHD medication frequently require higher doses to achieve meaningful appetite suppression, and even then outcomes can be more limited

Homocysteine can induce oxidative stress, inflammation, and vascular dysfunction, all of which can contribute to neurological damage

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It is also known that oral contraceptives may lower pyridoxine levels in some individuals, which could be considered a drug-nutrient interaction of clinical relevance