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Tips for managing constipation Drink plenty of water through the day Add fiber slowly, from foods such as fruit, vegetables, beans, and whole grains Stay physically active Give yourself unhurried time in the bathroom, ideally at the same time each day Ask your healthcare provider before starting a stool softener or laxative Contact your healthcare provider if constipation is painful, does not improve, or if you stop passing stool or gas entirely

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Genetically predicted l-carnitine was associated with higher risk of CAD in men (OR 1.07, 95% CI 1.01 to 1.14) but not women (OR 1.02, 95% CI 0.96 to 1.09), although the difference by sex did not reach statistical significance ( p value for sex difference 0.31) (Fig

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