glp-1 stroke risk Prevention and Treatment in People With Type 2 Diabetes: Is There a Role for (Glucagon-Like Peptide-1) Analogues? How Do GLP-1 Agonists Fit

The result is a reduction in blood glucose levels through a mechanism that is entirely separate from insulin

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In small proof-of-concept phase 2 randomized controlled trials (RCTs) in patients with biopsy-confirmed MASH, liraglutide at 1.8 mg/day for 48 weeks (201), semaglutide at 0.4 mg/day for 72 weeks (202), and tirzepatide at 15 mg/week for 52 weeks (203) have been reported to achieve placebo-corrected percentages of participants meeting the criteria for resolution of MASH without worsening fibrosis by 30% (P = 0.019), 42% (P 10%) may lead to diabetes remission (237)

They accumulate in the liver and have been linked to liver cancer and immunosuppression