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An invited commentary on this study, also published in JAMA Ophthalmology, challenges the idea that the increased risk of NAION among semaglutide users resulted directly from the medication
With a half-life around 5 days, tirzepatide is essentially cleared about 4 to 5 weeks after the final dose
The review notes that weight loss does not come from fat alone, rather, there is also a loss of lean body mass including skeletal muscle, organs, bone, body water, and connective tissue
While treatment guidelines provide evidence-based guidance, they are not prescriptiverather they emphasize individualization of management based on a patients clinical needs and preferences
