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Associations of the skin, oral and gut microbiome with aging, frailty and infection risk reservoirs in older adults
The incidence of fatal hepatotoxicity decreases considerably in progressively older patient groups
This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated
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