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The most notable study is the STEP 1 trial, a randomized, double-masked, placebo-controlled study published in the New England Journal of Medicine

Additionally, B12 injections can aid in the production of red blood cells, promoting healthy circulation and helping to prevent anemia, which supports cardiovascular health and mental clarity

Until one does, the correct statement is not that the combination is unsupported by strong evidence but that it is unstudied, which is a different and cleaner claim

While results vary by individual, consistency and professional oversight are key to achieving lasting improvements in skin brightness and clarity