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In particular, since the pivotal role of inflammation in COVID-19 life threatening complications had been identified shortly after the outbreak in Wuhan, particular attention should have been paid to identify the most active and appropriate anti-inflammatory medications, and recommend their prescription at the presentation of the early symptoms to prevent their progression (Sestili and Stocchi, 2020)

In DSS and TNBS induced colitis models, orally administered KPV has consistently reduced disease activity scores, lowered inflammatory cytokine levels, decreased mucosal damage, and helped restore gut barrier function