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The dose was MIC-informed: our in vitro MIC was 15.625 g/mL, and the intragastric concentration (~ 15 g/mL) was selected to achieve approximately 1MIC in the gastric lumen, prioritizing local (topical) gastric exposure over systemic delivery while minimizing vehicle load
Further, while SGLT2 inhibitors provide no protection against stroke, a benefit of the GLP-1 receptor agonist on this devastating outcome is well established
Notably, N-acetylcysteine, a precursor of GSH, that has been reported to be able to improve graft survival [9, 10]
Proper form and progressive programming remain the priority
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