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Also, ML351 specifically inhibits ALOX-15 and alleviates erastin-induced cardiac ischemia/reperfusion (I/R) injury (Horinouchi et al., 2024)

SURMOUNT-5 showed Mounjaro produces 6.5 percentage points more weight loss on average

Nat Protoc 2006

Genetic predispositions in the GLP1R pathway (variant rs6923761) may correlate with differential receptor sensitivity, suggesting some patients respond effectively at lower starting doses while others require gradual titration to therapeutic levels

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