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Glucagon receptor activity is hypothesised to increase energy expenditure and promote fat breakdown (lipolysis), which researchers believe may contribute to the substantial weight loss observed in early trials though these mechanisms continue to be investigated

The Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2 study a double-blind, placebo-controlled trial investigated the incremental effect of adding nicotinic acid (1 g/day) to statin therapy in 167 patients with known CHD and low HDL concentrations on carotid intima-media thickness (CIMT) (82), a surrogate endpoint for the development of atherosclerosis

Any mention of SUBCUTANEOUS administration

Although GLP-1 RAs are frequently recommended due to their cardiometabolic advantages, careful observation is necessary due to the possibility of increased gastrointestinal tissue proliferation and the corresponding risk of cancer