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Although semaglutide is approved for treatment of obesity, tirzepatide and CagriSema are still in clinical trials and not yet approved for obesity
Semaglutide injections are ideal for adults with a BMI of 27 or higher, particularly those with weight-related health conditions like high blood pressure, type 2 diabetes, or sleep apnea
Materials and Methods To date, there is one experimental structure determined by X-ray diffraction of the semaglutide backbone in complex with the extracellular domain (ECD) of GLP-1R (PDB ID: 4ZGM [29]), which is used here as the template for structural modeling by Modeller [44] and ligand-receptor binding affinity (K d ) calculations by Prodigy [45, 46]
Hepatol Res 47:890901
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