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Interestingly, a recent study in Danish population showed that lower serum vitamin B12 concentrations were significantly associated higher BMI, but a genetic risk score related to vitamin B12 concentrations associated variants was not associated with BMI

While both medications mimic the natural hormone, GLP-1, that regulates blood sugar and are effective for weight loss, tirzepatide has shown to lead to greater weight loss and improvements in insulin sensitivity

doi: 10.1016/j.pcad.2016.05.002 123