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Undetected and untreated, B12 deficiency can lead to a range of clinical problems, including reversible megaloblastic anemia and demyelinating neurologic disease
The safety profile of orforglipron in Phase 3 trials has been consistent with the GLP-1 receptor agonist class
In the United States, the FDA has also not yet approved retatrutide, though Eli Lilly has announced that it received Fast Track designation from the FDA for the treatment of obesity a status that facilitates more frequent communication between the developer and the regulator to help expedite the review process
"Combination Therapies for Obesity: Cagrilintide and GLP-1 Receptor Agonist Synergy." Nature Reviews Endocrinology, 18(9), 541-556
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