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A broad overview of the science behind growth-hormone-derived peptides is available through the National Center for Biotechnology Informations library of peer-reviewed research on peptide fragments and metabolic signaling, which underscores how preliminary much of this work remains

In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]

That said, patients with active diabetes or significant metabolic dysfunction should have any investigational peptide protocol reviewed by their endocrinologist or primary care physician alongside their supervising aesthetic medicine provider

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