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While GLP-1 and GIP receptor activation primarily drive satiety signalling and improved glucose handling, glucagon receptor engagement adds a thermogenic and lipolytic dimension

Patients also experienced a significant reduction in systolic blood pressure ( p = 0.002) and hepatic enzymes alanine transaminase (ALT) and aspartate transaminase (AST) (respectively, p = 0.0008 and p = 0.004), consistently with the significant weight loss obtained (Fig