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The molecular responses observed vary according to receptor subtype, peptide concentration, exposure time, cell model, and overall study design, and MTII is employed to characterise melanocortinreceptor signalling rather than to infer defined biological or physiological effects
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Those of targets center around nutrient-sensing hormones including GLP-1, GIP, glucagon, amylin, peptide tyrosine-tyrosine (PYY) and cholecystokinin (CCK)
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