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Our previous study, BARI-OPTIMISE, selectively recruited participants with suboptimal weight loss after MBS who also had a blunted meal-stimulated GLP-1 response, based on observational study data correlating higher native postprandial GLP-1 levels to higher %WL after MBS

Furthermore, GLP-1 RAs exhibit vasodilatory effects by promoting endothelial nitric oxide (NO) synthesis, enhancing endothelial function with a consequent reduction of vascular resistance and an improvement in cardiac afterload [45, 46]

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Compared to patients treated with sodium-dependent glucose transporters 2 (SGLT2) inhibitors as monotherapy, those receiving GLP-1RAs for type 2 diabetes exhibited a significantly increased risk of thyroid hyperplasia and thyroid cancer [22]