These include the following: therapeutic benefits resulting from non-antioxidant mechanisms, insufficient dosage to elicit an antioxidant effect, poor oral bioavailability, a narrow therapeutic index, or toxicity that precludes clinical use
Morgan AS, Ciaccio PJ, Tew KD and Kauvar LM
1 To understand whether non-diabetic patients prescribed GLP-1 medications experience similar rates of these gastrointestinal (GI) side effects, we studied 367,439 non-diabetic patients, including 170,842 who were on a GLP-1 medication and 196,597 who were on other weight loss medications
Cardiovascular outcomes data for Ozempic comes from the SELECT trial, which demonstrated a 20% reduction in major adverse cardiovascular events (heart attack, stroke, cardiovascular death) in patients with established heart disease but without diabetes