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Jastreboff, MD, PhD authored early clinical research that informs the broader scientific context around retatrutide ( New England Journal of Medicine , 2023) [3]
Functionally, TXNIP acts as a tumor suppressor through its downregulation in malignant cells, where it concurrently suppresses proliferation and metastatic potential and promotes apoptotic pathways (9193)
Its triple-agonism creates a broader metabolic effect than dual agonists like tirzepatide
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