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These hallmark lesions appear years, if not decades, before symptom onset and are associated with synaptic dysfunction, progressive neuronal loss, and widespread cortical and hippocampal atrophy
Preclinical studies generally support these clinical observations
Spectrophotometry of carnitine in biological fluids and tissue with a Cobas Bio Centrifugal Analyzer
Adenosine is known to mediate the intoxicating effect of alcohol [71-75], and A 2A R inhibition may increase reward-seeking behaviors when subjects are introduced to addictive substances or activities
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