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Converting that hypothesis into knowledge requires PCOS-specific clinical trials with metabolic and reproductive endpoints, adequate duration, and rigorous attention to fertility and pregnancy safety

Besides the 10 thermostabilizing mutations that reported previously 26,27 , E387 7.42b D was introduced to mimic the identified interaction in the GCGR-NNC1702 complex structure 9

The medication takes 4 to 5 weeks to reach steady-state blood levels, which is why the dose titration schedule starts low and increases gradually

The 4-week interval exists because shorter intervals (2 weeks) produce more side effects without additional efficacy, and longer intervals (6 to 8 weeks) allow too much receptor adaptation