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Haematological Isolated red cell macrocytoisis Macrocytic anaemia (especially if MCV more than 110fl) Pancytopenia (especially if MCV more than 120fl) Neurological or Psychiatric Optic neuropathy Peripheral neuropathy (sensory or motor) Symmetrical neuropathy affecting the legs more than the arms

The first attempts to measure intestinal permeability in IBD were performed in the late seventies by rectal instillation of radioiodine-labeled albumin and by measuring later the radioactivity in the plasma in healthy subjects and patients with UC (101)

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Some people also report that MIC B12 injections have helped with sleep, memory, and concentration