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Overexpression of RRM2 accelerates deoxynucleotide synthesis, competitively antagonizes the DNA intercalation of gemcitabine, and enhances DNA repair capacity, thereby weakening the efficacy of the drug (Zuo et al., 2024)

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On increasing the zonation level, as the zonation gradient maintained a similar average parameter, we observed a similar overall amount of maximum necrosed cells

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