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Increased fat synthesis based on enhanced glycolytic activity (pklr1, sterol regulatory element-binding protein-1 [SREBP1c], fas, and liver X receptor a [lxra]) in aged mice partly accounted for hepatic steatosis (increased leukocytic infiltration) and necrosis (increased plasma aspartate aminotransferase [AST] activity), compared with reduced srebp1c and fas mRNA levels in young mice
If using monotherapy at 4.5 mg/week, vial counts roughly double from the 2.4 mg/week math above
Osimo EF, Pillinger T, Rodriguez IM, Khandaker GM, Pariante CM, Howes OD
Nelson, M
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