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Intern Med 2014;53:192731
Multiple mechanisms contribute to this close relationship, including 18,19 : Endothelial dysfunction Volume overload and salt retention Overactivity of the sympathetic (fight-or-flight) nervous system Adverse changes in the hormonal regulation of blood pressure Dysfunction of the renin-angiotensin-aldosterone system Ultimately, in people with CKD and diabetes, kidney tissue and blood vessels are much more sensitive to pressure damage than those with uncomplicated mild-to-moderate high blood pressure
Efficacy and safety of dulaglutide added onto pioglitazone and metformin versus exenatide in type 2 diabetes in a randomized controlled trial (AWARD-1)
524,525 Pancreatic cancer Researchers first compared the expression of GLP-1R in human pancreatic cancer tissues with adjacent non-tumorous pancreatic tissues, finding generally lower or absent expression of GLP-1R in pancreatic cancer tissues
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