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GLP-1/amylin agonist: dual appetite and gastric modulation CagriSema, the fixed-ratio combination of semaglutide and cagrilintide, the long-acting amylin analog, produced 15.6% weight loss in 32 weekssuperior to semaglutide monotherapy in phase II trial [9]

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Inclusion criteria - Male and female individuals of at least 60 years of age at the time of the screening visit - Diagnosis of mild cognitive impairment (31) or dementia (32) due to AD according to NIA-AA 2011 criteria - Standardized mini-mental state examination score of at least 18 at the time of the screening visit - Living in a community setting without continuous nursing care - Can identify a reliable study partner with whom they have at least 3 weekly interactions to oversee study drug administration and participate in all clinic visits and some study procedures (including Cognitive Dementia Rating)

Some sensitive patients may benefit from microdosing (below 0.25 mg) or customized compounded formulations to improve tolerance