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The main research areas include endogenous growth hormone and IGF-1 signaling, visceral adipose tissue reduction, waist and trunk-fat changes, lean-body-mass measurements, lipid metabolism, hepatic fat, and skeletal-muscle composition

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In the SURPASS-2 trial, patients with obesity and T2D who received tirzeapatide (5 mg weekly) achieved greater HbA1c and body weight reductions than those receiving semaglutide (1 mg weekly) during the 40 week study (64) despite comparable putative GLP-1R occupancy at these doses (47)

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