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Two reviewers then independently screened titles, abstracts, and full texts against prespecified criteria, resolving disagreements by consensus

Some studies suggest the imbalanced inflammatory response results from immune system dysfunction, while others indicate a possible role for the internal microenvironment, with altered microbial composition contributing to the vulnerability of the intestinal lining to harm caused by free radical species

This makes it distinct in research examining endogenous sleep regulation mechanisms rather than pharmacological sleep induction